Features
- Cover Type: Hard Cover with 308 pages
- Published by: Wiley
- Edition: 1st Edition April 8, 2005
- Written in: English
- ISBN 10 Number: 0470021403
- ISBN 13 Number: 978-0470021408
-
Book Dimensions:
9 x 6 x 0.8 inches
- Weighs: 1.4 pounds
Product Review
"…a useful reference for current literature and developments on the cardiac hERG potassium channel. No other books are currently available on the subject." (
Doody's Health Services)
Product Description
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding.
It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks.
Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.
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