Features
- Cover Type: Hard Cover with 617 pages
- Published by: Academic Press
- Edition: 2nd Edition January 12, 2004
- Written in: English
- ISBN 10 Number: 0126437327
- ISBN 13 Number: 978-0126437324
-
Book Dimensions:
10.3 x 7.6 x 1.5 inches
- Weighs: 3.5 pounds
Product Review
Praise for the First Edition:"This book is a tour de force in the title areaThis book would be appropriate for advanced undergraduate students and graduate students…strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
"… unified, well-organized and clearly presented …It is so clearly written that it will be of value to both students and veteran scientistsMy congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."
--Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION
"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way"
--William C. Groutas, WICHITA STATE UNIVERSITY
"I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to readTreatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen"
--John G. Topliss, PARKE-DAVIS
"The organization of this book and the clarity of presentation are outstanding It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry."
--JOURNAL OF MEDICINAL CHEMISTRY --
Review
Product Review
"Sliverman continues to blur the edges between chemistry and pharmacology in a manner that is incontrovertibly relevant to the discipline of drug design and development."
-Michael E. Cooper, GE Healthcare, The Maynard Centre, in DDT, VOL. 9, 2004
"What stands out in comparison with other books discussed here is that the subjects are generally addressed in detail, and each theoretical point is illustrated with examples of specific drugs."
-ORGANIC CHEMISTRY ORG., 2005
Praise for the New Edition:
"this book is a thorough overview of drug discovery and development It is not only an great textbook for students but also a valuable resource for those already practicing medicinal chemistry."
--JOURNAL OF MEDICINAL CHEMISTRY
Praise for the First Edition:
"This book is a tour de forceappropriate for advanced undergraduate students and graduate studentsstrongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
" unified, well-organized and clearly presentedMy congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data "
--Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION
"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way"
--William C. Groutas, Wichita State University
"The organization of this book and the clarity of presentation are outstandingIt is highly recommended"
--JOURNAL OF MEDICINAL CHEMISTRY
Reader ReviewsThis is probably the best book of its kind in the vast and multidisciplinary field of drug design and action. Richard Silverman is an acclaimed chemistry Professor at Northwestern University, and in this book, he provides the most comprehensive and lucid exposition of the chemical basis of drug action that I have seen. No matter how complicated biological systems and their interactions are, at the basic level, it's all chemistry, and mostly organic chemistry. An organic chemist will find this book extremely illuminating in a way that would not have been made clear through his traditional education. The book opens with a short but clear discussion of drug discovery, combinatorial chemistry, and clinical testing and trials. Then it leads the reader through a variety of enzyme catalyzed reactions, with examples of major drugs studded all the way. Silverman shows us how nature is the master organic chemist, employing the familiar reactions of chemistry in an unsurpassed way. The chapter on enzyme inhibition is long and detailed, and it's breathtaking. Which is important because almost all major drugs act by inhibiting enzymes. The examples which Silverman chooses to illustrate are both important (including many bestselling anti-cancer, anti-viral, and antibiotic drugs to name a few), as well as very interesting. The last parts of the book deal with DNA binding drugs, and with pathways of drug metabolism and excretion. Along all the way, the emphasis is on the chemical reactions that drugs undergo, which after all is what controls their properties. The lucidity of the book is such that a beginning graduate well-versed with the basic principles of general and organic chemistry can easily understand all the contents. This book is so interesting and illuminating that it's one of the very few academic books which I have actually read from the first to the last page, with every word in between. In fact, it even makes great bedside reading! Truly a must-have book for all chemists and biologists of every kind, interested in how drugs work.
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