Protein Crystallography in Drug Discovery (Methods and Principles in Medicinal Chemistry)

Features

• Cover Type: Hard Cover with 278 pages
• Published by: Wiley-VCH
• Edition: 1st Edition March 5, 2004
• Written in: English
• ISBN 10 Number: 3527306781
• ISBN 13 Number: 978-3527306787
• Book Dimensions: 9.6 x 6.8 x 0.8 inches
• Weighs: 1.5 pounds

Product Review
"I would recommend this book as a reference for those wanting to get insight into what is important in the early stages of drug development." (Biochemistry and Molecular Education, July/ August 2004) "an important contribution to pharmaceutical research and development." (American Journal of Therapeutics, May/June 2004)

"Medicinal chemists will find the book invaluable whether they are working in an area of one of the chapters or wish to apply the methods described to other projects. Structural and computational biologists should also find it useful and thought-provoking." —Bill Gleason (ChemBioChem, August 6, 2004)

"I would recommend this book as a reference for those wanting to get insight into what is important in the early stages of drug development." (Biochemistry and Molecular Education, July/ August 2004)

"…an important contribution to pharmaceutical research and development." (American Journal of Therapeutics, May/June 2004)

Product Description
The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method.

Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included.

A valuable companion for crystallographers involved in protein structure determination as well as drug developers pursuing the structure-based approach for use in their daily work.