Features
- Cover Type: Hard Cover with 290 pages
- Published by: International University Line
- Edition: 1st Edition July 1, 2007
- Written in: English
- ISBN 10 Number: 097207743X
- ISBN 13 Number: 978-0972077439
-
Book Dimensions:
8.9 x 6.2 x 0.9 inches
- Weighs: 1.4 pounds
Product Review
During the 1980s and early 1990s, we observed a awesome breakthrough in our understanding of the physical chemistry of macromolecular crystallization due to the pioneering efforts of several leaders in the field. However, the determination of protein 3-dimensional structure was still a slow process, often taking years to complete. In the mid to late 1990s, a new renaissance of protein crystallography occurred with the development of increased throughput nanovolume crystallization robotic methods, microfluidic counter diffusion, creative screens and optimization techniques, crystal imaging, and novel crystallization methods for the very challenging membrane proteins and large macromolecular complexes. In the fast paced world of high throughput protein crystallization, this work was established by many of the authors in this book and the areas are comprehensively covered. Protein Crystallization Strategies for Structural Genomics will be highly valuable to those experimentalist interested in understanding, reproducing, or expanding upon the recent innovations. It will be an essential reference for the many small and medium size laboratories that are starting or are planning to adopt these systems and approaches. The clarity, thoroughness, and simplicity of the chapters are impressive. The best analogy for this enyclopedia is the early days of gene sequencing when technology development was critical in moving radioactive gel sequencing to fluorescent capillary automated methods. This book is the beginning of a similar movement, initiating the vision of rapid macromolecular structure determination for providing a deeper understanding of the molecular science of life. What this book accomplishes and that many other similar books miss are the critical details necessary to understand, and further expand upon protein crystallization strategies for structural biology. --Raymond C. Stevens, Professor, The Scripps Research Institute, La Jolla, CA
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