Cracking the Genome: Inside the Race to Unlock Human DNA

Features

• Cover Type: Paperback with 352 pages
• Published by: The Johns Hopkins University Press; Johns Hopkins Paberbacks Ed edition October 29, 2002
• Written in: English
• ISBN 10 Number: 0801871409
• ISBN 13 Number: 978-0801871405
• Book Dimensions: 9 x 6 x 1 inches
• Weighs: 1.1 pounds

Product Review
What makes science happen? The confluence of politics, commerce, and the age-old quest for knowledge is nowhere better seen than in the ongoing Human Genome Project. Kevin Davies, founding editor of Nature Genetics, picks apart the personalities and technologies involved in the great sequence race in Cracking the Genome: Inside the Race to Unlock Human DNA. Written not long after President Clinton's premature announcement in 2000 of the Project's completion, it assesses the state of public and private genomic knowledge during what Davies calls "halftime." He is in a unique observational position; as a prominent scientific journalist, he has had unparalleled access to the scientific figures involved. Through interviews with HGP director Francis Collins, rogue scientist-entrepreneur J. Craig Venter, and many other scientists and insiders, Davies illuminates the often-tortured processes that contributed to the speedy sequencing of most--but not quite all--of our genes in just a few short years. Shifting styles characterize the different storylines: technological, political, and intensely personal tales unite under the author's direction without ever alienating the reader. The book is a bit softer on Venter than many scientists (who may perceive him as traitorous or, worse, too hasty to publish) would like, taking the position that his shotgun approach and competitive spirit improved the project without sacrificing quality. Conversely, Davies sits out the gene-patenting controversy, offering all sides a fairly equal voice, but never quite finding sympathy with any of them. Summing up his subject, Davies reports:

If the double helix is the prevailing image of the twentieth century, just as the steam engine signified the nineteenth century, then the sequence--the vast expanse of 3 billion As, Cs, Gs, and Ts--is destined to define the century to come. The childhood of the human race is about to come to an end.

These are strong words, but few other fields provide a stronger basis for such hope. Cracking the Genome gives us the chance to catch up with the present while the future races on. --Rob Lightner --This text refers to an out of print or unavailable edition of this title.

From Publishers Weekly
The Human Genome Project, the effort to determine the full genetic composition of human beings, has consumed billions of dollars, involved thousands of scientists, captured the imaginations of millions of people and offered the promise of untold numbers of medical breakthroughs. Davies, founding editor of the journal Nature Genetics and author of Breakthrough: The Race to find the Breast Cancer Gene, does an impressive job of contextualizing the science within a political, economic and social framework, creating a lively tale as accessible to nonspecialists as it is to scientists. A quest for profits as well as accolades is shown to be an important force in shaping "what is, at the very least, an extraordinary technological achievement, and is at best perhaps the defining moment in the evolution of mankind." Most of the leading scientists involved, individuals such as James Watson, Nobel laureate and original director of the Human Genome Project; Francis Collins, Watson's successor; and J. Craig Venter, the entrepreneurial scientist who decided to compete with the publicly funded Human Genome Project using private money and untested computational methods, spoke openly with Davies about their hopes and desires. Davies does a fine job describing the basic molecular biology and genetics underlying the Project as well as many of the ways our newfound knowledge may be put to use, though he largely ignores the ethical considerations swirling around a lot of these options. (Jan.) Forecast: The Free Press hopes publication will coincide with the public joint release of the human genome sequence by the Human Genome Project and Craig Venter's Celera Genomics. Spurred by that burst of publicity, the same readers who put Matt Ridley's Genome on the New York Times paperback bestseller list may provide brisk sales of this title as well.
Copyright 2000 Reed Business Information, Inc. --This text refers to an out of print or unavailable edition of this title.

Reader Reviews
This review is from: Cracking The Genome: Inside The Race To Unlock Human Dna (Hardcover) This is an extremely readable account of personalities and events that have occurred in the genome field during the last decade (plus some). It is basically two books. One is the story about the politics and events surrounding the public and private efforts to sequence the human genome. The other is a brief survey of medical genetics to put the genome sequencing effort in context. By medical genetics I mean the genetically unusual and useful individuals and populations that geneticists study to find and understand disease genes. For example: the Huntington's disease story. The medical genetics stories have all been reported on in other books of this type but the comprehensive account of the public/private genome efforts is worth reading to those who have been following the magazine and newspaper accounts. It essentially collates all of the stories and news bites of the last several years into a single coherent narrative. As an earlier review noted it is short on science but that is what makes the book a good read. You can pick up the minimal science facts necessary from many other books and web sites. I've been an engineer in the DOE genome program for about ten years now. Many of the stories in the book I've heard first hand from people who were either in the room or were participants in the events. It is as accurate a version as any I've seen. Usually I shy away from these types of books but this one is a must read if you really want to get beyond the hype of the popular press.