Features
- Cover Type: Hard Cover with 814 pages
- Published by: Cold Spring Harbor Laboratory Press
- Edition: 1st Edition August 30, 2006
- Written in: English
- ISBN 10 Number: 0879697660
- ISBN 13 Number: 978-0879697662
-
Book Dimensions:
5.3 x 1.5 x 1.2 inches
- Weighs: 3.2 pounds
Product Review
this book provides a broad and current synthesis of our understanding of genome duplication and it should be on the bookshelves of all students of DNA replication. -Carol S. Newlon --Nature Cell Biology
Product Description
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than twenty trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome, and at least forty diseases are caused by aberrant DNA replication, 35 by mutations in genes required for DNA replication or repair, 7 by mutations generated during mitochondrial DNA replication, and more than forty by DNA viruses. Consequently, a growing number of therapeutic drugs are targeted to DNA replication proteins. This authoritative volume provides a rich source of information for researchers, physicians, and teachers, and will stimulate thinking about the relevance of DNA replication to human disease.
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