Features
- Cover Type: Hard Cover with 504 pages
- Published by: Humana Press
- Edition: 1st Edition October 22, 2004
- Written in: English
- ISBN 10 Number: 1588290840
- ISBN 13 Number: 978-1588290847
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Book Dimensions:
9.1 x 6.2 x 1.2 inches
- Weighs: 1.8 pounds
Product Review
"This book should be of interest to both specialist researchers as well as members of the wider scientific community" - British Journal of Anesthesiology
Product Description
A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.
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