Features
- Cover Type: Hard Cover with 800 pages
- Published by: Wiley-VCH
- Edition: 1st Edition August 29, 2003
- Written in: English
- ISBN 10 Number: 390639025X
- ISBN 13 Number: 978-3906390253
-
Book Dimensions:
9.7 x 7.1 x 1.8 inches
- Weighs: 4.5 pounds
Product Review
"This book provides an outstanding and comprehensive review of metabolic reactions catalyzed by hydrolytic enzymes…and their role in the biotransformation of xenobiotic substances." (
Journal of the American Chemical Society, December 22, 2004)
"For the first time, the metabolic reactions of hydrolysis…of drugs, prodrugs, and many other xenobiotics are tightly and comprehensively organized under a single cover.” (
Pharmaceutical Research, June 2004)
"In summary, this book succeeds on many levels. At once it provides a clear and well-organized introduction to hydrolysis reactions in drug metabolism and drug design, a enyclopedia of reaction mechanisms with extensive examples, and a comprehensive and eloquent treatise on the similarities, differences, and unifying principles of these reactions in metabolism.” (
Journal of Medicinal Chemistry, 2004, Vol. 47, No. 10)
Product Description
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically.
Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
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