Features
- Cover Type: Paperback with 512 pages
- Published by: Wiley-Liss
- Edition: 2nd Edition May 5, 2006
- Written in: English
- ISBN 10 Number: 0471089524
- ISBN 13 Number: 978-0471089520
-
Book Dimensions:
9.1 x 6.1 x 1 inches
- Weighs: 1.6 pounds
Product Description
Second Edition features the latest tools for uncovering the genetic basis of human disease The
Second Edition of this landmark publication brings together a team of leading experts in the field to thoroughly update the publication. Readers will discover the awesome advances made in human genetics in the seven years that have elapsed since the
First Edition. Once again, the editors have assembled a comprehensive introduction to the strategies, designs, and methods of analysis for the discovery of genes in common and genetically complex traits. The growing social, legal, and ethical issues surrounding the field are thoroughly examined as well.
Rather than focusing on technical details or particular methodologies, the editors take a broader approach that emphasizes concepts and experimental design. Readers familiar with the
First Edition will find new and cutting-edge material incorporated into the text:
- Updated presentations of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family-based approaches, and genomic screening
- New methods for analysis of gene-gene and gene-environment interactions
- A completely rewritten and updated chapter on determining genetic components of disease
- New chapters covering molecular genomic approaches such as microarray and SAGE analyses using single nucleotide polymorphism (SNP) and cDNA expression data, as well as quantitative trait loci (QTL) mapping
The editors, two of the world's leading genetic epidemiologists, have ensured that each chapter adheres to a consistent and high standard. Each one includes all-new discussion questions and practical examples. Chapter summaries highlight key points, and a list of references for each chapter opens the door to further investigation of specific topics.
Molecular biologists, human geneticists, genetic epidemiologists, and clinical and pharmaceutical researchers will find the
Second Edition a helpful guide to understanding the genetic basis of human disease, with its new tools for detecting risk factors and discovering treatment strategies.
Back Cover Copy
Second Edition features the latest tools for uncovering the genetic basis of human disease The Second Edition of this landmark publication brings together a team of leading experts in the field to thoroughly update the publication. Readers will discover the awesome advances made in human genetics in the seven years that have elapsed since the First Edition. Once again, the editors have assembled a comprehensive introduction to the strategies, designs, and methods of analysis for the discovery of genes in common and genetically complex traits. The growing social, legal, and ethical issues surrounding the field are thoroughly examined as well.
Rather than focusing on technical details or particular methodologies, the editors take a broader approach that emphasizes concepts and experimental design. Readers familiar with the First Edition will find new and cutting-edge material incorporated into the text:
- Updated presentations of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family-based approaches, and genomic screening
- New methods for analysis of gene-gene and gene-environment interactions
- A completely rewritten and updated chapter on determining genetic components of disease
- New chapters covering molecular genomic approaches such as microarray and SAGE analyses using single nucleotide polymorphism (SNP) and cDNA expression data, as well as quantitative trait loci (QTL) mapping
The editors, two of the world's leading genetic epidemiologists, have ensured that each chapter adheres to a consistent and high standard. Each one includes all-new discussion questions and practical examples. Chapter summaries highlight key points, and a list of references for each chapter opens the door to further investigation of specific topics.
Molecular biologists, human geneticists, genetic epidemiologists, and clinical and pharmaceutical researchers will find the Second Edition a helpful guide to understanding the genetic basis of human disease, with its new tools for detecting risk factors and discovering treatment strategies.
Reader ReviewsI bought this book on the recommendation of a professor but it really isn't that good of book. It is already out of date as it focuses primarily on linkage analysis with only a cursory look at association studies. Moreover most of the coverage of association is family based studies and not the more common case-control design. Finally, I bought this book b/c it mentions that it covers multiple comparisons - my area of research. It doesn't at all! There is a slight mention that multiple comparisons can be a problem but that is it! There are much better books out there...
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